PolarProtDb

Gene name

SDC1 (Synd1,Synd-1,SDC)

Experiment(s)

For this entry:

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	22	Signal peptide
23	252	Extracellular
253	275	Membrane
276	310	Cytoplasmic

Phosphorylation

Position	Resource
285	469564
286	458494
287	15428544
299	458495
309	455075

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
37	UniProtKB
45	UniProtKB
47	UniProtKB
56	O-GlycoProteomDB
58	O-GlycoProteomDB
61	PhosphoSitePlus
61	dbPTM		55826851
61	O-GlycoProteomDB
63	O-GlycoProteomDB
64	O-GlycoProteomDB
68	O-GlycoProteomDB
72	PhosphoSitePlus
72	dbPTM		55832533
72	O-GlycoProteomDB
76	PhosphoSitePlus
76	dbPTM		55832539
76	O-GlycoProteomDB
77	O-GlycoProteomDB
77	PhosphoSitePlus
77	dbPTM		55832545
81	PhosphoSitePlus
81	dbPTM		55832549
81	O-GlycoProteomDB
86	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
86	O-GlycoProteomDB
89	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
89	UniCarbKB	$WURCS=2.0/2,6,5/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-1-2-2-2/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30459171
89	O-GlycoProteomDB
90	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
90	O-GlycoProteomDB
90	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
90	UniCarbKB	$WURCS=2.0/2,6,5/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-1-2-2-2/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30459171
90	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
91	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
91	O-GlycoProteomDB
92	UniCarbKB		30459171
92	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
92	O-GlycoProteomDB
115	O-GlycoProteomDB
122	PhosphoSitePlus
122	dbPTM		55830737
122	O-GlycoProteomDB
128	O-GlycoProteomDB
129	O-GlycoProteomDB
133	O-GlycoProteomDB
134	O-GlycoProteomDB
139	O-GlycoProteomDB
140	O-GlycoProteomDB
141	O-GlycoProteomDB
143	O-GlycoProteomDB
144	O-GlycoProteomDB
150	O-GlycoProteomDB
151	O-GlycoProteomDB
164	PhosphoSitePlus
164	O-GlycoProteomDB
164	dbPTM		55826991
164	UniCarbKB	$WURCS=2.0/2,5,4/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-1-2-2/a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?_a?\|b?\|c?\|d?\|e?}-{a?\|b?\|c?\|d?\|e?$	30459171
165	PhosphoSitePlus
165	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
165	dbPTM		55826997
165	O-GlycoProteomDB
166	PhosphoSitePlus
166	UniCarbKB		30459171
166	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
166	dbPTM		55827003
166	O-GlycoProteomDB
171	O-GlycoProteomDB
171	PhosphoSitePlus
171	dbPTM		55827007
177	PhosphoSitePlus
177	dbPTM		55827011
177	O-GlycoProteomDB
180	PhosphoSitePlus
180	dbPTM		55827015
180	O-GlycoProteomDB
186	PhosphoSitePlus
186	dbPTM		55827019
186	O-GlycoProteomDB
188	dbPTM		55827025
188	PhosphoSitePlus
188	O-GlycoProteomDB
197	O-GlycoProteomDB
198	O-GlycoProteomDB
198	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
206	UniProtKB
212	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
215	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
216	UniProtKB
216	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
220	O-GlycoProteomDB
220	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
220	UniCarbKB		30459171
231	N-GlycoSiteAtlas		22106898
240	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
240	PhosphoSitePlus
240	dbPTM		51510761
240	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Neurexin-like
InterPro	Syndecan
InterPro	Syndecan-1
InterPro	Syndecan/Neurexin_dom
InterPro	Syndecan_CS
Pfam	Syndecan

Interactions

With (links to EBI)	#Exp	PubMed links
ESR1_HUMAN	2	31527615
PDPK1_HUMAN	2	31980649

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.