Gene name
SDC1 (Synd1,Synd-1,SDC)
Experiment(s)
For this entry:
SDC1_MOUSE (SDC1)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Maday S,Anderson E,Chang HC,Shorter J,Satoh A,Sfakianos J,Fölsch H,Anderson JM,Walther Z,Mellman I (2008) A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells., Traffic, 9, 1915-24. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Localization depends on PDZ motif. A Myc epitope was used for labelling |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 22 | Signal peptide |
| 23 | 252 | Extracellular |
| 253 | 276 | Membrane |
| 277 | 311 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 306 | 311 | Basolateral plasma membrane | PDZ-ligand |
Maday S,Anderson E,Chang HC,Shorter J,Satoh A,Sfakianos J,Fölsch H,Anderson JM,Walther Z,Mellman I (2008) A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells., Traffic, 9, 1915-24. [PubMed][DOI] |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Neurexin-like |
| InterPro | Syndecan |
| InterPro | Syndecan-1 |
| InterPro | Syndecan/Neurexin_dom |
| InterPro | Syndecan_CS |
| Pfam | Syndecan |