Gene name
SLC5A8 (slc5a8,SMCT,SMCT1,AIT,ECO:0000303|PubMed:15090606})
Experiment(s)
For this entry:
SC5A8_MOUSE (SLC5A8)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Gopal E,Umapathy NS,Martin PM,Ananth S,Gnana-Prakasam JP,Becker H,Wagner CA,Ganapathy V,Prasad PD (2007) Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney., Biochim Biophys Acta, 1768, 2690-7. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 11 | Extracellular |
| 12 | 32 | Membrane |
| 33 | 53 | Cytoplasmic |
| 54 | 74 | Membrane |
| 75 | 85 | Extracellular |
| 86 | 107 | Membrane |
| 108 | 128 | Cytoplasmic |
| 129 | 149 | Membrane |
| 150 | 161 | Extracellular |
| 162 | 182 | Membrane |
| 183 | 189 | Cytoplasmic |
| 190 | 210 | Membrane |
| 211 | 240 | Extracellular |
| 241 | 259 | Membrane |
| 260 | 279 | Cytoplasmic |
| 280 | 301 | Membrane |
| 302 | 339 | Extracellular |
| 340 | 361 | Membrane |
| 362 | 382 | Cytoplasmic |
| 383 | 403 | Membrane |
| 404 | 413 | Extracellular |
| 414 | 434 | Membrane |
| 435 | 441 | Cytoplasmic |
| 442 | 462 | Membrane |
| 463 | 521 | Extracellular |
| 522 | 542 | Membrane |
| 543 | 611 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 202 | 25753948 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Glc_symporter_sf |
| InterPro | Na/solute_symporter |
| InterPro | SLC5sbd_SMCT1 |
| Pfam | SSF |