PolarProtDb

Gene name

SLC5A8 (slc5a8,SMCT,SMCT1,AIT,ECO:0000303|PubMed:15090606})

Experiment(s)

For this entry:

SC5A8_HUMAN (SLC5A8)

Species	Homo sapiens
Localization	Apical plasma membrane
Reference	Lacroix L,Pourcher T,Magnon C,Bellon N,Talbot M,Intaraphairot T,Caillou B,Schlumberger M,Bidart JM (2004) Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters., J Clin Endocrinol Metab, 89, 1423-8. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Thyroid gland
Cell	Follicular cells
Notes

For ortholog entries:

SC5A8_MOUSE

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	14	Extracellular
15	33	Membrane
34	53	Cytoplasmic
54	74	Membrane
75	85	Extracellular
86	107	Membrane
108	128	Cytoplasmic
129	149	Membrane
150	161	Extracellular
162	182	Membrane
183	189	Cytoplasmic
190	210	Membrane
211	240	Extracellular
241	259	Membrane
260	279	Cytoplasmic
280	301	Membrane
302	338	Extracellular
339	360	Membrane
361	381	Cytoplasmic
382	403	Membrane
404	412	Extracellular
413	434	Membrane
435	441	Cytoplasmic
442	462	Membrane
463	521	Extracellular
522	542	Membrane
543	610	Cytoplasmic

Phosphorylation

Position	Resource
64	22778127
74	22778130
79	13310356
576	50799933

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
493	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
498	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
498	UniCarbKB	$WURCS=2.0/2,6,5/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-1-2-2-2/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30459171
499	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171

Family and domain data

Database	Domain/Family name
InterPro	Na/Glc_symporter_sf
InterPro	Na/solute_symporter
InterPro	SLC5sbd_SMCT1
Pfam	SSF