Gene name
Slc40a1 (Fpn1,Ireg1,Slc11a3,Slc39a1,Fpt1)
Experiment(s)
For this entry:
S40A1_RAT (Slc40a1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Non polar membrane |
| Reference |
Núñez MT,Tapia V,Rojas A,Aguirre P,Gómez F,Nualart F (2010) Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1., Am J Physiol Cell Physiol, 298, C477-85. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes | Localization is dynamic |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Cytoplasmic |
| 26 | 41 | Membrane |
| 42 | 57 | Extracellular |
| 58 | 80 | Membrane |
| 81 | 93 | Cytoplasmic |
| 94 | 115 | Membrane |
| 116 | 126 | Extracellular |
| 127 | 147 | Membrane |
| 148 | 182 | Cytoplasmic |
| 183 | 198 | Membrane |
| 199 | 201 | Extracellular |
| 202 | 223 | Membrane |
| 224 | 306 | Cytoplasmic |
| 307 | 327 | Membrane |
| 328 | 340 | Extracellular |
| 341 | 361 | Membrane |
| 362 | 372 | Cytoplasmic |
| 373 | 393 | Membrane |
| 394 | 450 | Extracellular |
| 451 | 471 | Membrane |
| 472 | 491 | Cytoplasmic |
| 492 | 512 | Membrane |
| 513 | 517 | Extracellular |
| 518 | 538 | Membrane |
| 539 | 570 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ferroportin-1 |
| InterPro | MFS_trans_sf |
| Pfam | FPN1 |