Gene name
Slc40a1 (Fpn1,Ireg1,Slc11a3,Slc39a1,Fpt1)
Experiment(s)
For this entry:
S40A1_HUMAN (Slc40a1)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Núñez MT,Tapia V,Rojas A,Aguirre P,Gómez F,Nualart F (2010) Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1., Am J Physiol Cell Physiol, 298, C477-85. [PubMed] [DOI] |
| Evidence level | Other |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes | A membrane side-specific biotinylation and purification scheme was followed |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Cytoplasmic |
| 26 | 41 | Membrane |
| 42 | 57 | Extracellular |
| 58 | 80 | Membrane |
| 81 | 93 | Cytoplasmic |
| 94 | 115 | Membrane |
| 116 | 126 | Extracellular |
| 127 | 147 | Membrane |
| 148 | 182 | Cytoplasmic |
| 183 | 198 | Membrane |
| 199 | 203 | Extracellular |
| 204 | 224 | Membrane |
| 225 | 306 | Cytoplasmic |
| 307 | 327 | Membrane |
| 328 | 340 | Extracellular |
| 341 | 362 | Membrane |
| 363 | 372 | Cytoplasmic |
| 373 | 393 | Membrane |
| 394 | 451 | Extracellular |
| 452 | 472 | Membrane |
| 473 | 492 | Cytoplasmic |
| 493 | 513 | Membrane |
| 514 | 518 | Extracellular |
| 519 | 539 | Membrane |
| 540 | 571 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ferroportin-1 |
| InterPro | MFS_trans_sf |
| Pfam | FPN1 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| A4_HUMAN | 5 | 20817278 |
| B3AT_HUMAN | 3 | 23219802 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.