Gene name
Slc26a4 (Pds)
Experiment(s)
For this entry:
S26A4_HUMAN (Slc26a4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Gillam MP,Sidhaye AR,Lee EJ,Rutishauser J,Stephan CW,Kopp P (2004) Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux., J Biol Chem, 279, 13004-10. [PubMed] [DOI] |
| Evidence level | Functional assay |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A heterologously expressed transporter assay was used |
S26A4_HUMAN (Slc26a4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Skubis-Zegadło J,Nikodemska A,Przytuła E,Mikula M,Bardadin K,Ostrowski J,Wenzel BE,Czarnocka B (2005) Expression of pendrin in benign and malignant human thyroid tissues., Br J Cancer, 93, 144-51. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Thyroid gland |
| Cell | Follicular cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 87 | Cytoplasmic |
| 88 | 108 | Membrane |
| 109 | 113 | Extracellular |
| 114 | 131 | Membrane |
| 132 | 135 | Cytoplasmic |
| 136 | 156 | Membrane |
| 157 | 185 | Extracellular |
| 186 | 206 | Membrane |
| 207 | 218 | Cytoplasmic |
| 219 | 239 | Membrane |
| 240 | 267 | Extracellular |
| 268 | 285 | Membrane |
| 286 | 299 | Cytoplasmic |
| 300 | 317 | Membrane |
| 318 | 347 | Extracellular |
| 348 | 368 | Membrane |
| 369 | 384 | Cytoplasmic |
| 385 | 405 | Membrane |
| 406 | 421 | Extracellular |
| 422 | 442 | Membrane |
| 443 | 447 | Cytoplasmic |
| 448 | 466 | Membrane |
| 467 | 482 | Extracellular |
| 483 | 510 | Membrane |
| 511 | 780 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Pendrin |
| InterPro | S04_transporter_CS |
| InterPro | SLC26A/SulP_dom |
| InterPro | SLC26A/SulP_fam |
| InterPro | STAS_dom |
| InterPro | STAS_dom_sf |
| Pfam | STAS |
| Pfam | Sulfate_transp |