Gene name
SLC23A2 (KIAA0238,SVCT2,YSPL2,NBTL1,SLC23A1)
Experiment(s)
For this entry:
S23A2_HUMAN (SLC23A2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kuo SM,Wang LY,Yu S,Campbell CE,Valiyaparambil SA,Rance M,Blumenthal KM (2013) The N-terminal basolateral targeting signal unlikely acts alone in the differential trafficking of membrane transporters in MDCK cells., Biochemistry, 52, 5103-5116. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Basolateral localization depends on classical dileucine-type motif EDTELM |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 104 | Cytoplasmic |
| 105 | 125 | Membrane |
| 126 | 139 | Extracellular |
| 140 | 158 | Membrane |
| 159 | 163 | Cytoplasmic |
| 164 | 182 | Membrane |
| 183 | 214 | Extracellular |
| 215 | 234 | Membrane |
| 235 | 240 | Cytoplasmic |
| 241 | 259 | Membrane |
| 260 | 268 | Extracellular |
| 269 | 287 | Membrane |
| 288 | 310 | Cytoplasmic |
| 311 | 332 | Membrane |
| 333 | 371 | Extracellular |
| 372 | 392 | Membrane |
| 393 | 457 | Cytoplasmic |
| 458 | 478 | Membrane |
| 479 | 485 | Extracellular |
| 486 | 506 | Membrane |
| 507 | 516 | Cytoplasmic |
| 517 | 534 | Membrane |
| 535 | 548 | Extracellular |
| 549 | 568 | Membrane |
| 569 | 650 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 51 | 57 | Basolateral plasma membrane | Dileucine-like |
Kuo SM,Wang LY,Yu S,Campbell CE,Valiyaparambil SA,Rance M,Blumenthal KM (2013) The N-terminal basolateral targeting signal unlikely acts alone in the differential trafficking of membrane transporters in MDCK cells., Biochemistry, 52, 5103-5116. [PubMed][DOI] |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 188 | N-GlycoSiteAtlas | 24190977 | |
| 188 | PolarProtDb | 31844046 | |
| 196 | N-GlycoSiteAtlas | 24190977 | |
| 196 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | SlC23A2 |
| InterPro | Xan_ur_permease |
| InterPro | Xant/urac/vitC |
| Pfam | Xan_ur_permease |