Gene name
SLC22A12 (URAT1,OATL4)
Experiment(s)
For this entry:
S22AC_MOUSE (SLC22A12)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Tomioka NH,Nakamura M,Doshi M,Deguchi Y,Ichida K,Morisaki T,Hosoyamada M (2013) Ependymal cells of the mouse brain express urate transporter 1 (URAT1)., Fluids Barriers CNS, 10, 31. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes |
S22AC_MOUSE (SLC22A12)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Toyoki D,Shibata S,Kuribayashi-Okuma E,Xu N,Ishizawa K,Hosoyamada M,Uchida S (2017) Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2., Am J Physiol Renal Physiol, 313, F826-F834. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 12 | Cytoplasmic |
| 13 | 32 | Membrane |
| 33 | 146 | Extracellular |
| 147 | 166 | Membrane |
| 167 | 174 | Cytoplasmic |
| 175 | 194 | Membrane |
| 195 | 200 | Extracellular |
| 201 | 222 | Membrane |
| 223 | 231 | Cytoplasmic |
| 232 | 252 | Membrane |
| 253 | 259 | Extracellular |
| 260 | 279 | Membrane |
| 280 | 349 | Cytoplasmic |
| 350 | 369 | Membrane |
| 370 | 378 | Extracellular |
| 379 | 399 | Membrane |
| 400 | 406 | Cytoplasmic |
| 407 | 426 | Membrane |
| 427 | 435 | Extracellular |
| 436 | 456 | Membrane |
| 457 | 466 | Cytoplasmic |
| 467 | 488 | Membrane |
| 489 | 494 | Extracellular |
| 495 | 515 | Membrane |
| 516 | 553 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| Pfam | Sugar_tr |