Gene name
SLC22A12 (URAT1,OATL4)
Experiment(s)
For this entry:
S22AC_HUMAN (SLC22A12)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Enomoto A,Kimura H,Chairoungdua A,Shigeta Y,Jutabha P,Cha SH,Hosoyamada M,Takeda M,Sekine T,Igarashi T,Matsuo H,Kikuchi Y,Oda T,Ichida K,Hosoya T,Shimokata K,Niwa T,Kanai Y,Endou H (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels., Nature, 417, 447-52. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
S22AC_HUMAN (SLC22A12)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Enomoto A,Endou H (2005) Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease., Clin Exp Nephrol, 9, 195-205. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Cytoplasmic |
| 18 | 37 | Membrane |
| 38 | 146 | Extracellular |
| 147 | 166 | Membrane |
| 167 | 173 | Cytoplasmic |
| 174 | 194 | Membrane |
| 195 | 200 | Extracellular |
| 201 | 221 | Membrane |
| 222 | 231 | Cytoplasmic |
| 232 | 252 | Membrane |
| 253 | 259 | Extracellular |
| 260 | 279 | Membrane |
| 280 | 349 | Cytoplasmic |
| 350 | 369 | Membrane |
| 370 | 379 | Extracellular |
| 380 | 400 | Membrane |
| 401 | 407 | Cytoplasmic |
| 408 | 427 | Membrane |
| 428 | 434 | Extracellular |
| 435 | 455 | Membrane |
| 456 | 467 | Cytoplasmic |
| 468 | 488 | Membrane |
| 489 | 494 | Extracellular |
| 495 | 515 | Membrane |
| 516 | 553 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| Pfam | Sugar_tr |