Gene name
Slc15a2 (Pept2)
Experiment(s)
For this entry:
S15A2_RABIT (Slc15a2)
| Species | Oryctolagus cuniculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Klapper M,Daniel H,Döring F (2006) Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein., Am J Physiol Cell Physiol, 290, C472-83. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | SKPT-0193 Cl.2 cells (proximal tubules) |
| Notes | " C-terminal truncations or mutations abolish apical location (due to terminal EGFP tagging |
S15A2_RABIT (Slc15a2)
| Species | Oryctolagus cuniculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Klapper M,Daniel H,Döring F (2006) Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein., Am J Physiol Cell Physiol, 290, C472-83. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | OK cells (proximal tubule) |
| Notes | " C-terminal truncations or mutations abolish apical location (due to terminal EGFP tagging |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 57 | Cytoplasmic |
| 58 | 75 | Membrane |
| 76 | 84 | Extracellular |
| 85 | 104 | Membrane |
| 105 | 113 | Cytoplasmic |
| 114 | 133 | Membrane |
| 134 | 142 | Extracellular |
| 143 | 160 | Membrane |
| 161 | 185 | Cytoplasmic |
| 186 | 205 | Membrane |
| 206 | 216 | Extracellular |
| 217 | 237 | Membrane |
| 238 | 298 | Cytoplasmic |
| 299 | 316 | Membrane |
| 317 | 345 | Extracellular |
| 346 | 363 | Membrane |
| 364 | 379 | Cytoplasmic |
| 380 | 397 | Membrane |
| 398 | 614 | Extracellular |
| 615 | 630 | Membrane |
| 631 | 646 | Cytoplasmic |
| 647 | 666 | Membrane |
| 667 | 674 | Extracellular |
| 675 | 695 | Membrane |
| 696 | 729 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Alpha/beta_knot_MTases |
| InterPro | MFS_trans_sf |
| InterPro | Oligopep_transport |
| InterPro | POT_fam |
| InterPro | PTR2_symporter_CS |
| Pfam | PTR2 |