Gene name
PTPRO (GLEPP1,Ptpn15,PTPU2)
Experiment(s)
For this entry:
Q62797_RAT (PTPRO)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Hinkes B,Wiggins RC,Gbadegesin R,Vlangos CN,Seelow D,Nürnberg G,Garg P,Verma R,Chaib H,Hoskins BE,Ashraf S,Becker C,Hennies HC,Goyal M,Wharram BL,Schachter AD,Mudumana S,Drummond I,Kerjaschki D,Waldherr R,Dietrich A,Ozaltin F,Bakkaloglu A,Cleper R,Basel-Vanagaite L,Pohl M,Griebel M,Tsygin AN,Soylu A,Müller D,Sorli CS,Bunney TD,Katan M,Liu J,Attanasio M,O'toole JF,Hasselbacher K,Mucha B,Otto EA,Airik R,Kispert A,Kelley GG,Smrcka AV,Gudermann T,Holzman LB,Nürnberg P,Hildebrandt F (2006) Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible., Nat Genet, 38, 1397-405. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Podocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 30 | Signal peptide |
| 31 | 820 | Extracellular |
| 821 | 844 | Membrane |
| 845 | 1216 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FN3_dom |
| InterPro | FN3_sf |
| InterPro | Ig-like_fold |
| InterPro | Prot-tyrosine_phosphatase-like |
| InterPro | PTPase_domain |
| InterPro | PTPRO |
| InterPro | Tyr_Pase_AS |
| InterPro | Tyr_Pase_cat |
| InterPro | TYR_PHOSPHATASE_dom |
| Pfam | fn3 |
| Pfam | Y_phosphatase |