Gene name
Slc10a2 (Ntcp2,ASBT,ISBT)
Experiment(s)
For this entry:
NTCP2_RAT (Slc10a2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Lazaridis KN,Pham L,Tietz P,Marinelli RA,deGroen PC,Levine S,Dawson PA,LaRusso NF (1997) Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter., J Clin Invest, 100, 2714-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
NTCP2_RAT (Slc10a2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Lazaridis KN,Pham L,Tietz P,Marinelli RA,deGroen PC,Levine S,Dawson PA,LaRusso NF (1997) Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter., J Clin Invest, 100, 2714-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
NTCP2_RAT (Slc10a2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Christie DM,Dawson PA,Thevananther S,Shneider BL (1996) Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum., Am J Physiol, 271, G377-85. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
NTCP2_RAT (Slc10a2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Christie DM,Dawson PA,Thevananther S,Shneider BL (1996) Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum., Am J Physiol, 271, G377-85. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 28 | Extracellular |
| 29 | 51 | Membrane |
| 52 | 66 | Cytoplasmic |
| 67 | 89 | Membrane |
| 90 | 96 | Extracellular |
| 97 | 117 | Membrane |
| 118 | 124 | Cytoplasmic |
| 125 | 147 | Membrane |
| 148 | 161 | Extracellular |
| 162 | 182 | Membrane |
| 183 | 195 | Cytoplasmic |
| 196 | 216 | Membrane |
| 217 | 223 | Extracellular |
| 224 | 245 | Membrane |
| 246 | 261 | Cytoplasmic |
| 262 | 277 | Membrane |
| 278 | 285 | Extracellular |
| 286 | 308 | Membrane |
| 309 | 348 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | BilAc:Na_symport/Acr3 |
| InterPro | Bilac:Na_transpt |
| InterPro | Na+/solute_symporter_sf |
| InterPro | SLC10A2 |
| Pfam | SBF |