Gene name
Slc10a2 (Ntcp2,ASBT,ISBT)
Experiment(s)
For this entry:
NTCP2_MOUSE (Slc10a2)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Dawson PA,Hubbert M,Haywood J,Craddock AL,Zerangue N,Christian WV,Ballatori N (2005) The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter., J Biol Chem, 280, 6960-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 31 | Extracellular |
| 32 | 53 | Membrane |
| 54 | 66 | Cytoplasmic |
| 67 | 88 | Membrane |
| 89 | 95 | Extracellular |
| 96 | 117 | Membrane |
| 118 | 126 | Cytoplasmic |
| 127 | 148 | Membrane |
| 149 | 161 | Extracellular |
| 162 | 182 | Membrane |
| 183 | 192 | Cytoplasmic |
| 193 | 215 | Membrane |
| 216 | 224 | Extracellular |
| 225 | 245 | Membrane |
| 246 | 261 | Cytoplasmic |
| 262 | 277 | Membrane |
| 278 | 286 | Extracellular |
| 287 | 308 | Membrane |
| 309 | 348 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 335 | 453445 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | BilAc:Na_symport/Acr3 |
| InterPro | Bilac:Na_transpt |
| InterPro | Na+/solute_symporter_sf |
| InterPro | SLC10A2 |
| Pfam | SBF |