Gene name
MUC5AC (MUC5)
Experiment(s)
For this entry:
MUC5A_HUMAN (MUC5AC)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 5654 | Extracellular |
Phosphorylation
| Position | Resource |
|---|---|
| 599 | 50784054 |
| 698 | 55374087 |
| 768 | 34353894 |
| 775 | 34353897 |
| 988 | 50831027 |
| 1258 | 55530175 |
| 1269 | 55530177 |
| 1270 | 55530179 |
| 1279 | 12429494 |
| 1291 | 6196601 |
| 1467 | 12428747 |
| 1511 | 34368641 |
| 1512 | 34368643 |
| 1834 | 6196600 |
| 1877 | 5264744 |
| 1896 | 11126189 |
| 1897 | 11126192 |
| 3157 | 36276218 |
| 3161 | 36276220 |
| 3313 | 10165072 |
| 3611 | 10165075 |
| 4044 | 10165078 |
| 4718 | 10165081 |
| 5502 | 56569272 |
| 5504 | 56569274 |
| 5628 | 50831023 |
| 5643 | 50831025 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Cys_knot_C |
| InterPro | Ser_inhib-like_sf |
| InterPro | TIL_dom |
| InterPro | Unchr_dom_Cys-rich |
| InterPro | VWF_dom |
| InterPro | VWF_type-D |
| InterPro | WxxW_domain |
| Pfam | C8 |
| Pfam | Mucin2_WxxW |
| Pfam | TIL |
| Pfam | VWD |