Gene name
MUC1 (PUM)
Experiment(s)
For this entry:
MUC1_HUMAN (MUC1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Kinlough CL,Poland PA,Gendler SJ,Mattila PE,Mo D,Weisz OA,Hughey RP (2011) Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal., J Biol Chem, 286, 39072-81. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | The O-glycans were found to be critical for apical targeting |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 23 | Signal peptide |
| 24 | 1159 | Extracellular |
| 1160 | 1181 | Membrane |
| 1182 | 1255 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Mucin-1 |
| InterPro | SEA_dom |
| InterPro | SEA_dom_sf |
| Pfam | SEA |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| EGFR_HUMAN | 3 | 24658140 , 31980649 |
| U2AF2_HUMAN | 2 | 22905162 |
| AQP3_HUMAN | 3 | 32296183 |
| AQP1_HUMAN | 3 | 32296183 |
| AQP2_HUMAN | 3 | 32296183 |
| MAL2_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.