Gene name
Abcc3 (CMOAT2,MLP2,MRP3)
Experiment(s)
For this entry:
MRP3_RAT (Abcc3)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Ortiz DF,Li S,Iyer R,Zhang X,Novikoff P,Arias IM (1999) MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte., Am J Physiol, 276, G1493-500. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes | This data conflicts with later studies |
MRP3_RAT (Abcc3)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rost D,Mahner S,Sugiyama Y,Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine., Am J Physiol Gastrointest Liver Physiol, 282, G720-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
MRP3_RAT (Abcc3)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rost D,Mahner S,Sugiyama Y,Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine., Am J Physiol Gastrointest Liver Physiol, 282, G720-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Extracellular |
| 36 | 56 | Membrane |
| 57 | 73 | Cytoplasmic |
| 74 | 93 | Membrane |
| 94 | 103 | Extracellular |
| 104 | 123 | Membrane |
| 124 | 134 | Cytoplasmic |
| 135 | 154 | Membrane |
| 155 | 170 | Extracellular |
| 171 | 190 | Membrane |
| 191 | 299 | Cytoplasmic |
| 300 | 319 | Membrane |
| 320 | 343 | Extracellular |
| 344 | 364 | Membrane |
| 365 | 422 | Cytoplasmic |
| 423 | 443 | Membrane |
| 444 | 447 | Extracellular |
| 448 | 467 | Membrane |
| 468 | 532 | Cytoplasmic |
| 533 | 554 | Membrane |
| 555 | 564 | Extracellular |
| 565 | 584 | Membrane |
| 585 | 961 | Cytoplasmic |
| 962 | 982 | Membrane |
| 983 | 1006 | Extracellular |
| 1007 | 1028 | Membrane |
| 1029 | 1080 | Cytoplasmic |
| 1081 | 1101 | Membrane |
| 1102 | 1103 | Extracellular |
| 1104 | 1123 | Membrane |
| 1124 | 1189 | Cytoplasmic |
| 1190 | 1210 | Membrane |
| 1211 | 1219 | Extracellular |
| 1220 | 1239 | Membrane |
| 1240 | 1522 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |