Gene name
Abcc3 (CMOAT2,MLP2,MRP3)
Experiment(s)
For this entry:
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Gall bladder |
| Cell | Epithelial cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
König J,Rost D,Cui Y,Keppler D (1999) Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane., Hepatology, 29, 1156-63. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kool M,van der Linden M,de Haas M,Scheffer GL,de Vree JM,Smith AJ,Jansen G,Peters GJ,Ponne N,Scheper RJ,Elferink RP,Baas F,Borst P (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs., Proc Natl Acad Sci U S A, 96, 6914-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Rost D,König J,Weiss G,Klar E,Stremmel W,Keppler D (2001) Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia., Gastroenterology, 121, 1203-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Gall bladder |
| Cell | Epithelial cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Gall bladder |
| Cell | Epithelial cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Kool M,de Haas M,de Vree JM,Pijnenborg AC,Bosman DK,Elferink RP,van der Valk P,Borst P,Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3., Lab Invest, 82, 193-201. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D (2005) Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma., Int J Cancer, 115, 359-67. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Azzaroli F,Mennone A,Feletti V,Simoni P,Baglivo E,Montagnani M,Rizzo N,Pelusi G,DE Aloysio D,Lodato F,Festi D,Colecchia A,Roda E,Boyer JL,Mazzella G (2007) Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid., Aliment Pharmacol Ther, 26, 1139-46. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Keiser M,Kaltheuner L,Wildberg C,Müller J,Grube M,Partecke LI,Heidecke CD,Oswald S (2017) The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers., J Pharm Sci, 106, 2657-2663. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes | Membranes were analyzed by targeted mass spectrometry instead of western blotting |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kool M,van der Linden M,de Haas M,Scheffer GL,de Vree JM,Smith AJ,Jansen G,Peters GJ,Ponne N,Scheper RJ,Elferink RP,Baas F,Borst P (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs., Proc Natl Acad Sci U S A, 96, 6914-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
MRP3_HUMAN (Abcc3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kool M,van der Linden M,de Haas M,Scheffer GL,de Vree JM,Smith AJ,Jansen G,Peters GJ,Ponne N,Scheper RJ,Elferink RP,Baas F,Borst P (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs., Proc Natl Acad Sci U S A, 96, 6914-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Extracellular |
| 36 | 56 | Membrane |
| 57 | 73 | Cytoplasmic |
| 74 | 93 | Membrane |
| 94 | 103 | Extracellular |
| 104 | 124 | Membrane |
| 125 | 134 | Cytoplasmic |
| 135 | 154 | Membrane |
| 155 | 170 | Extracellular |
| 171 | 190 | Membrane |
| 191 | 305 | Cytoplasmic |
| 306 | 326 | Membrane |
| 327 | 347 | Extracellular |
| 348 | 367 | Membrane |
| 368 | 424 | Cytoplasmic |
| 425 | 445 | Membrane |
| 446 | 449 | Extracellular |
| 450 | 470 | Membrane |
| 471 | 535 | Cytoplasmic |
| 536 | 556 | Membrane |
| 557 | 566 | Extracellular |
| 567 | 585 | Membrane |
| 586 | 965 | Cytoplasmic |
| 966 | 987 | Membrane |
| 988 | 1011 | Extracellular |
| 1012 | 1033 | Membrane |
| 1034 | 1085 | Cytoplasmic |
| 1086 | 1107 | Membrane |
| 1108 | 1109 | Extracellular |
| 1110 | 1129 | Membrane |
| 1130 | 1194 | Cytoplasmic |
| 1195 | 1216 | Membrane |
| 1217 | 1223 | Extracellular |
| 1224 | 1244 | Membrane |
| 1245 | 1527 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 1006 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| MLH1_HUMAN | 2 | 20706999 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.