Gene name
ABCC2 (Cmoat,CMOAT1,Cmrp,Mrp2)
Experiment(s)
For this entry:
MRP2_RAT (ABCC2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Miller DS,Nobmann SN,Gutmann H,Toeroek M,Drewe J,Fricker G (2000) Xenobiotic transport across isolated brain microvessels studied by confocal microscopy., Mol Pharmacol, 58, 1357-67. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MRP2_RAT (ABCC2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Scheffer GL,Hu X,Pijnenborg AC,Wijnholds J,Bergen AA,Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors., Lab Invest, 82, 515-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
MRP2_RAT (ABCC2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Rius M,Nies AT,Hummel-Eisenbeiss J,Jedlitschky G,Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane., Hepatology, 38, 374-84. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 29 | Extracellular |
| 30 | 50 | Membrane |
| 51 | 63 | Cytoplasmic |
| 64 | 85 | Membrane |
| 86 | 97 | Extracellular |
| 98 | 118 | Membrane |
| 119 | 128 | Cytoplasmic |
| 129 | 150 | Membrane |
| 151 | 161 | Extracellular |
| 162 | 183 | Membrane |
| 184 | 313 | Cytoplasmic |
| 314 | 334 | Membrane |
| 335 | 353 | Extracellular |
| 354 | 374 | Membrane |
| 375 | 431 | Cytoplasmic |
| 432 | 452 | Membrane |
| 453 | 456 | Extracellular |
| 457 | 477 | Membrane |
| 478 | 541 | Cytoplasmic |
| 542 | 563 | Membrane |
| 564 | 574 | Extracellular |
| 575 | 596 | Membrane |
| 597 | 968 | Cytoplasmic |
| 969 | 990 | Membrane |
| 991 | 1020 | Extracellular |
| 1021 | 1042 | Membrane |
| 1043 | 1094 | Cytoplasmic |
| 1095 | 1115 | Membrane |
| 1116 | 1117 | Extracellular |
| 1118 | 1138 | Membrane |
| 1139 | 1201 | Cytoplasmic |
| 1202 | 1222 | Membrane |
| 1223 | 1232 | Extracellular |
| 1233 | 1252 | Membrane |
| 1253 | 1541 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC2 |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |