Gene name
SLC16A3 (MCT4,Mct3)
Experiment(s)
For this entry:
MOT4_HUMAN (SLC16A3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Two basolateral signals were identified in the cytoplasmic tail |
MOT4_HUMAN (SLC16A3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Large intestine |
| Cell | Enterocytes |
| Notes |
MOT4_HUMAN (SLC16A3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Philp NJ,Wang D,Yoon H,Hjelmeland LM (2003) Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells., Invest Ophthalmol Vis Sci, 44, 1716-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | ARPE-19 cells (pigment epithel cells) |
| Notes |
MOT4_HUMAN (SLC16A3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 39 | Membrane |
| 40 | 60 | Extracellular |
| 61 | 82 | Membrane |
| 83 | 88 | Cytoplasmic |
| 89 | 108 | Membrane |
| 109 | 113 | Extracellular |
| 114 | 135 | Membrane |
| 136 | 145 | Cytoplasmic |
| 146 | 167 | Membrane |
| 168 | 177 | Extracellular |
| 178 | 197 | Membrane |
| 198 | 227 | Cytoplasmic |
| 228 | 249 | Membrane |
| 250 | 262 | Extracellular |
| 263 | 284 | Membrane |
| 285 | 293 | Cytoplasmic |
| 294 | 314 | Membrane |
| 315 | 319 | Extracellular |
| 320 | 340 | Membrane |
| 341 | 354 | Cytoplasmic |
| 355 | 375 | Membrane |
| 376 | 385 | Extracellular |
| 386 | 407 | Membrane |
| 408 | 465 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 422 | 434 | Basolateral plasma membrane | Unknown |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed][DOI] |
| 441 | 447 | Basolateral plasma membrane | Dileucine-like |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed][DOI] |
Phosphorylation
Family and domain data
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| HDAC7_HUMAN | 3 | 32296183 |
| DLG1_HUMAN | 2 | 30126976 |
| UBQL1_HUMAN | 3 | 32296183 |
| UBQL2_HUMAN | 3 | 32296183 |
| HPCA_HUMAN | 5 | 32296183 |
| FAM9B_HUMAN | 3 | 25416956 |
| BANP_HUMAN | 3 | 25416956 |
| NR2CA_HUMAN | 3 | 25416956 |
| CXA8_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.