Gene name
SLC16A8 (Mct3)
Experiment(s)
For this entry:
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Deora AA,Philp N,Hu J,Bok D,Rodriguez-Boulan E (2005) Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia., Proc Natl Acad Sci U S A, 102, 16245-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Two basolateral signals were identified in the cytoplasmic tail |
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Large intestine |
| Cell | Enterocytes |
| Notes |
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Deora AA,Philp N,Hu J,Bok D,Rodriguez-Boulan E (2005) Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia., Proc Natl Acad Sci U S A, 102, 16245-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Philp NJ,Wang D,Yoon H,Hjelmeland LM (2003) Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells., Invest Ophthalmol Vis Sci, 44, 1716-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
MOT3_HUMAN (SLC16A8)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Cytoplasmic |
| 18 | 39 | Membrane |
| 40 | 56 | Extracellular |
| 57 | 78 | Membrane |
| 79 | 85 | Cytoplasmic |
| 86 | 105 | Membrane |
| 106 | 112 | Extracellular |
| 113 | 134 | Membrane |
| 135 | 143 | Cytoplasmic |
| 144 | 164 | Membrane |
| 165 | 173 | Extracellular |
| 174 | 194 | Membrane |
| 195 | 252 | Cytoplasmic |
| 253 | 274 | Membrane |
| 275 | 287 | Extracellular |
| 288 | 309 | Membrane |
| 310 | 318 | Cytoplasmic |
| 319 | 339 | Membrane |
| 340 | 343 | Extracellular |
| 344 | 365 | Membrane |
| 366 | 376 | Cytoplasmic |
| 377 | 398 | Membrane |
| 399 | 411 | Extracellular |
| 412 | 433 | Membrane |
| 434 | 504 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 5 | 8 | GPRR | TRG_ER_diArg_1 |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 455 | 467 | Basolateral plasma membrane | Unknown |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed][DOI] |
| 476 | 482 | Basolateral plasma membrane | Dileucine-like |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed][DOI] |