Gene name
Slc16a1 (Mct1)
Experiment(s)
For this entry:
MOT1_RAT (Slc16a1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Non polar membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MOT1_RAT (Slc16a1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Philp NJ,Yoon H,Grollman EF (1998) Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE., Am J Physiol, 274, R1824-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 16 | Cytoplasmic |
| 17 | 37 | Membrane |
| 38 | 57 | Extracellular |
| 58 | 79 | Membrane |
| 80 | 86 | Cytoplasmic |
| 87 | 106 | Membrane |
| 107 | 111 | Extracellular |
| 112 | 133 | Membrane |
| 134 | 143 | Cytoplasmic |
| 144 | 165 | Membrane |
| 166 | 175 | Extracellular |
| 176 | 195 | Membrane |
| 196 | 255 | Cytoplasmic |
| 256 | 277 | Membrane |
| 278 | 290 | Extracellular |
| 291 | 312 | Membrane |
| 313 | 321 | Cytoplasmic |
| 322 | 342 | Membrane |
| 343 | 346 | Extracellular |
| 347 | 368 | Membrane |
| 369 | 382 | Cytoplasmic |
| 383 | 402 | Membrane |
| 403 | 414 | Extracellular |
| 415 | 436 | Membrane |
| 437 | 494 | Cytoplasmic |
Phosphorylation
Family and domain data
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| BASI_HUMAN | 4 | 17127621 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.