Gene name

Slc16a1 (Mct1)

Experiment(s)

For this entry:
MOT1_RAT (Slc16a1)
Species Rattus norvegicus
Localization Non polar membrane
Reference Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Vessels
Cell Brain capillary endothelial cells
Notes
MOT1_RAT (Slc16a1)
Species Rattus norvegicus
Localization Apical plasma membrane
Reference Philp NJ,Yoon H,Grollman EF (1998) Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE., Am J Physiol, 274, R1824-8.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Retina
Cell Pigment epithel cells
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 16 Cytoplasmic
17 37 Membrane
38 57 Extracellular
58 79 Membrane
80 86 Cytoplasmic
87 106 Membrane
107 111 Extracellular
112 133 Membrane
134 143 Cytoplasmic
144 165 Membrane
166 175 Extracellular
176 195 Membrane
196 255 Cytoplasmic
256 277 Membrane
278 290 Extracellular
291 312 Membrane
313 321 Cytoplasmic
322 342 Membrane
343 346 Extracellular
347 368 Membrane
369 382 Cytoplasmic
383 402 Membrane
403 414 Extracellular
415 436 Membrane
437 494 Cytoplasmic
Phosphorylation

Family and domain data

Database Domain/Family name
InterPro MCT
InterPro MCT1
InterPro MFS
InterPro MFS_dom
InterPro MFS_trans_sf
Pfam MFS_1

Interactions

With (links to EBI) #Exp PubMed links
BASI_HUMAN 4 17127621
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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