Gene name
Slc16a1 (Mct1)
Experiment(s)
For this entry:
MOT1_HUMAN (Slc16a1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Castorino JJ,Deborde S,Deora A,Schreiner R,Gallagher-Colombo SM,Rodriguez-Boulan E,Philp NJ (2011) Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia., Traffic, 12, 483-98. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
MOT1_HUMAN (Slc16a1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Large intestine |
| Cell | Enterocytes |
| Notes |
MOT1_HUMAN (Slc16a1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Deora AA,Philp N,Hu J,Bok D,Rodriguez-Boulan E (2005) Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia., Proc Natl Acad Sci U S A, 102, 16245-50. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
MOT1_HUMAN (Slc16a1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Philp NJ,Wang D,Yoon H,Hjelmeland LM (2003) Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells., Invest Ophthalmol Vis Sci, 44, 1716-21. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Pigment epithel cells |
| Notes |
MOT1_HUMAN (Slc16a1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Gill RK,Saksena S,Alrefai WA,Sarwar Z,Goldstein JL,Carroll RE,Ramaswamy K,Dudeja PK (2005) Expression and membrane localization of MCT isoforms along the length of the human intestine., Am J Physiol Cell Physiol, 289, C846-52. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 16 | Cytoplasmic |
| 17 | 37 | Membrane |
| 38 | 57 | Extracellular |
| 58 | 79 | Membrane |
| 80 | 86 | Cytoplasmic |
| 87 | 106 | Membrane |
| 107 | 111 | Extracellular |
| 112 | 133 | Membrane |
| 134 | 143 | Cytoplasmic |
| 144 | 165 | Membrane |
| 166 | 175 | Extracellular |
| 176 | 195 | Membrane |
| 196 | 262 | Cytoplasmic |
| 263 | 284 | Membrane |
| 285 | 297 | Extracellular |
| 298 | 319 | Membrane |
| 320 | 328 | Cytoplasmic |
| 329 | 349 | Membrane |
| 350 | 353 | Extracellular |
| 354 | 375 | Membrane |
| 376 | 389 | Cytoplasmic |
| 390 | 409 | Membrane |
| 410 | 421 | Extracellular |
| 422 | 443 | Membrane |
| 444 | 500 | Cytoplasmic |
Phosphorylation
Family and domain data
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| OTUB1_HUMAN | 2 | 26752685 |
| COQ9_HUMAN | 2 | 27499296 |
| Q77M19_MEASW | 2 | 21911578 |
| NDUA4_HUMAN | 2 | 27499296 |
| LRRK2_HUMAN | 2 | 31046837 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.