Gene name
Abcb1 (Mdr1,Pgy1,Mdr1b)
Experiment(s)
For this entry:
MDR1_RAT (Abcb1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Rao VV,Dahlheimer JL,Bardgett ME,Snyder AZ,Finch RA,Sartorelli AC,Piwnica-Worms D (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier., Proc Natl Acad Sci U S A, 96, 3900-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes |
MDR1_RAT (Abcb1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MDR1_RAT (Abcb1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Roberts LM,Woodford K,Zhou M,Black DS,Haggerty JE,Tate EH,Grindstaff KK,Mengesha W,Raman C,Zerangue N (2008) Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier., Endocrinology, 149, 6251-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MDR1_RAT (Abcb1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Rost D,Mahner S,Sugiyama Y,Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine., Am J Physiol Gastrointest Liver Physiol, 282, G720-6. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 42 | Cytoplasmic |
| 43 | 67 | Membrane |
| 68 | 117 | Extracellular |
| 118 | 138 | Membrane |
| 139 | 185 | Cytoplasmic |
| 186 | 207 | Membrane |
| 208 | 214 | Extracellular |
| 215 | 235 | Membrane |
| 236 | 291 | Cytoplasmic |
| 292 | 312 | Membrane |
| 313 | 333 | Extracellular |
| 334 | 354 | Membrane |
| 355 | 708 | Cytoplasmic |
| 709 | 730 | Membrane |
| 731 | 754 | Extracellular |
| 755 | 775 | Membrane |
| 776 | 829 | Cytoplasmic |
| 830 | 851 | Membrane |
| 852 | 858 | Extracellular |
| 859 | 879 | Membrane |
| 880 | 934 | Cytoplasmic |
| 935 | 956 | Membrane |
| 957 | 976 | Extracellular |
| 977 | 995 | Membrane |
| 996 | 1277 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | P-loop_NTPase |
| InterPro | Type_I_exporter |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |