Gene name
SLC7A5 (LAT1,MPE16,Ta1,LAT,CD98LC,ECO:0000303|PubMed:11557028})
Experiment(s)
For this entry:
LAT1_RAT (SLC7A5)
| Species | Rattus norvegicus |
|---|---|
| Localization | Non polar membrane |
| Reference |
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation., Neuroscience, 155, 423-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 50 | Cytoplasmic |
| 51 | 72 | Membrane |
| 73 | 84 | Extracellular |
| 85 | 105 | Membrane |
| 106 | 132 | Cytoplasmic |
| 133 | 154 | Membrane |
| 155 | 170 | Extracellular |
| 171 | 190 | Membrane |
| 191 | 200 | Cytoplasmic |
| 201 | 220 | Membrane |
| 221 | 247 | Extracellular |
| 248 | 267 | Membrane |
| 268 | 280 | Cytoplasmic |
| 281 | 302 | Membrane |
| 303 | 326 | Extracellular |
| 327 | 348 | Membrane |
| 349 | 378 | Cytoplasmic |
| 379 | 395 | Membrane |
| 396 | 400 | Extracellular |
| 401 | 422 | Membrane |
| 423 | 435 | Cytoplasmic |
| 436 | 457 | Membrane |
| 458 | 462 | Extracellular |
| 463 | 482 | Membrane |
| 483 | 512 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AA/rel_permease1 |
| InterPro | L_AA_transporter |
| Pfam | AA_permease_2 |