Gene name
SLC7A5 (LAT1,MPE16,Ta1,LAT,CD98LC,ECO:0000303|PubMed:11557028})
Experiment(s)
For this entry:
LAT1_HUMAN (SLC7A5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Okamoto Y,Sakata M,Ogura K,Yamamoto T,Yamaguchi M,Tasaka K,Kurachi H,Tsurudome M,Murata Y (2002) Expression and regulation of 4F2hc and hLAT1 in human trophoblasts., Am J Physiol Cell Physiol, 282, C196-204. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 50 | Cytoplasmic |
| 51 | 71 | Membrane |
| 72 | 83 | Extracellular |
| 84 | 104 | Membrane |
| 105 | 128 | Cytoplasmic |
| 129 | 150 | Membrane |
| 151 | 169 | Extracellular |
| 170 | 190 | Membrane |
| 191 | 199 | Cytoplasmic |
| 200 | 220 | Membrane |
| 221 | 241 | Extracellular |
| 242 | 262 | Membrane |
| 263 | 276 | Cytoplasmic |
| 277 | 297 | Membrane |
| 298 | 321 | Extracellular |
| 322 | 343 | Membrane |
| 344 | 371 | Cytoplasmic |
| 372 | 390 | Membrane |
| 391 | 395 | Extracellular |
| 396 | 417 | Membrane |
| 418 | 430 | Cytoplasmic |
| 431 | 452 | Membrane |
| 453 | 457 | Extracellular |
| 458 | 478 | Membrane |
| 479 | 507 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 230 | N-GlycoSiteAtlas | 22106898 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AA/rel_permease1 |
| InterPro | L_AA_transporter |
| Pfam | AA_permease_2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| TGON2_HUMAN | 2 | 29568061 |
| TM216_HUMAN | 2 | 26638075 |
| ELK1_HUMAN | 2 | 31980649 |
| CAV2_HUMAN | 2 | 31980649 |
| TMM17_HUMAN | 2 | 26638075 |
| LRRK2_HUMAN | 2 | 31046837 |
| ESR1_HUMAN | 2 | 31527615 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.