Gene name
IGFBP6 (Igfbp-6,IBP6)
Experiment(s)
For this entry:
IBP6_MOUSE (IGFBP6)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Shalamanova L,Kübler B,Storch S,Scharf JG,Braulke T (2008) Multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells., Mol Cell Endocrinol, 295, 18-23. [PubMed] [DOI] |
| Evidence level | Selective medium analysis |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | O-glycosylation did affect sorting but it was already apical in its absence |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 238 | Extracellular |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | IGFBP-6 |
| InterPro | IGFBP-like |
| InterPro | IGFBP_1-6_chordata |
| InterPro | Insulin_GF-bd_Cys-rich_CS |
| InterPro | Thyroglobulin_1 |
| InterPro | Thyroglobulin_1_sf |
| Pfam | Thyroglobulin_1 |