PolarProtDb

Gene name

IGFBP6 (Igfbp-6,IBP6)

Experiment(s)

For this entry:

IBP6_HUMAN (IGFBP6)

Species	Homo sapiens
Localization	Apical plasma membrane
Reference	Remacle-Bonnet M,Garrouste F,el Atiq F,Marvaldi J,Pommier G (1995) Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells., J Clin Invest, 96, 192-200. [PubMed] [DOI]
Evidence level	Selective medium analysis
Organ	Large intestine
Cell	HT29-D4 cells (enterocytes)
Notes	Endogenous protein was detected

For ortholog entries:

IBP6_MOUSE

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	240	Extracellular

Phosphorylation

Position	Resource
204	28110301
231	34361988
233	34354920

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
120	PolarProtDb		30350625
120	PhosphoSitePlus
120	O-GlycoProteomDB
120	PolarProtDb		30350625
120	dbPTM		55825225
126	dbPTM		55825231
126	UniProtKB		19838169 , 9572875
126	O-GlycoProteomDB
126	OGlycoBase		98241382
126	Glyconnect	$WURCS=2.0/3,4,3/[Aad21122h-2x_2-6_5NCC/3=O][axxxxh-1x_1-5_2NCC/3=O][axxxxh-1x_1-5]/1-1-2-3/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30237853
126	PolarProtDb		29296958
126	PolarProtDb		29296958
126	PolarProtDb	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30033600
126	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	23234360
126	Glyconnect	$WURCS=2.0/2,2,1/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2/a?\|b?}-{a?\|b?$	19838169 , 23234360
126	UniCarbKB		30459171 , 26598643
126	PhosphoSitePlus
126	UniCarbKB	$WURCS=2.0/3,3,2/[AUd21122h_5NCC/3=O][uxxxxh_2NCC/3=O][uxxxxh]/1-2-3/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171 , 26598643
143	O-GlycoProteomDB
144	OGlycoBase		98241382
144	O-GlycoProteomDB
144	UniProtKB
145	UniProtKB
145	O-GlycoProteomDB
145	dbPTM		9572875
145	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
145	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
145	OGlycoBase		98241382
146	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
146	dbPTM		9572875
146	OGlycoBase		98241382
146	O-GlycoProteomDB
146	UniProtKB
148	O-GlycoProteomDB
152	O-GlycoProteomDB
152	UniProtKB
152	OGlycoBase		98241382
152	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
158	O-GlycoProteomDB
176	PhosphoSitePlus
176	dbPTM		55834601
176	O-GlycoProteomDB
184	PhosphoSitePlus
184	dbPTM		55825363
184	O-GlycoProteomDB
204	PhosphoSitePlus
204	dbPTM		56220401
236	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Growth_fac_rcpt_cys_sf
InterPro	IGFBP-6
InterPro	IGFBP-like
InterPro	IGFBP_1-6_chordata
InterPro	Thyroglobulin_1
InterPro	Thyroglobulin_1_sf
Pfam	Thyroglobulin_1

Interactions

With (links to EBI)	#Exp	PubMed links
PPB1_HUMAN	3	32296183
X5D778_HUMAN	3	32296183
PO4F2_HUMAN	3	32296183
ENKD1_HUMAN	3	32296183
FBLN3_HUMAN	3	32296183
IBP6_HUMAN	3	32296183
DRC4_HUMAN	3	32296183
SDCB1_HUMAN	3	32296183
FBLN4_HUMAN	3	32296183
MSGN1_HUMAN	3	32296183
ZN417_HUMAN	5	32296183
GET3_HUMAN	3	32296183
SGTA_HUMAN	3	32296183
KR108_HUMAN	3	32296183
CDIPT_HUMAN	3	32296183
EPDR1_HUMAN	3	32296183
MBD3_HUMAN	3	32296183
KRA59_HUMAN	3	32296183
PKHA7_HUMAN	3	32296183
ZN587_HUMAN	3	32296183
KRA57_HUMAN	3	32296183
RBP10_HUMAN	3	32296183
UBQL4_HUMAN	2	16713569
PGTB2_HUMAN	3	32296183
MEIS2_HUMAN	3	32296183
CC116_HUMAN	3	32296183
AQP1_HUMAN	3	32296183
NCALD_HUMAN	3	32296183
UBAC1_HUMAN	3	32296183
UBQL1_HUMAN	3	32296183
UBQL2_HUMAN	3	32296183
Q7Z6N9_HUMAN	3	32296183
CREB5_HUMAN	3	32296183
CA074_HUMAN	3	32296183
MCSP_HUMAN	3	32296183

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.