PolarProtDb

Gene name

GDF15 (MIC1,ECO:0000303|PubMed:28081177},Sbf,PDF,PLAB,PTGFB)

Experiment(s)

For this entry:

GDF15_HUMAN (GDF15)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes	Only mock-transfected cells were considered

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	308	Extracellular

Phosphorylation

Position	Resource
146	31084192

Glycosylation

Position	Site resource	PubMed link(s)
31	O-GlycoProteomDB
36	PolarProtDb	29296958
36	O-GlycoProteomDB
39	O-GlycoProteomDB
44	PhosphoSitePlus
44	dbPTM	55828353
44	O-GlycoProteomDB
48	O-GlycoProteomDB
65	O-GlycoProteomDB
70	N-GlycoSiteAtlas	23090970
70	PolarProtDb	31844046
268	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Cystine-knot_cytokine
InterPro	TGF-b_C
InterPro	TGF-beta-rel
Pfam	TGF_beta

Interactions

With (links to EBI)	#Exp	PubMed links
HXA1_HUMAN	3	32296183
CBX3_HUMAN	3	32296183
KR122_HUMAN	3	32296183
MDFI_HUMAN	5	19060904 , 32296183
NLGN3_HUMAN	2	25464930
TACC3_HUMAN	3	32296183

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.