Gene name

FBLN1

Experiment(s)

For this entry:
FBLN1_HUMAN (FBLN1)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807.
[PubMed] [DOI]
Evidence level Large-scale proteomics
Organ Lung
Cell Airway epithel cells
Notes Only mock-transfected cells were considered
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 703 Extracellular
Phosphorylation
Glycosylation

Family and domain data

Database Domain/Family name
InterPro Anaphylatoxin/fibulin
InterPro cEGF
InterPro EGF-like_Ca-bd_dom
InterPro EGF-like_dom
InterPro EGF-type_Asp/Asn_hydroxyl_site
InterPro EGF_Ca-bd_CS
InterPro Fibulin-1
InterPro Growth_fac_rcpt_cys_sf
Pfam cEGF
Pfam EGF_CA

Interactions

With (links to EBI) #Exp PubMed links
1433T_HUMAN 2 21988832
SMAD3_HUMAN 2 21988832
ATN1_HUMAN 2 16713569
NLGN3_HUMAN 2 25464930
APOA1_HUMAN 2 21988832
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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