Gene name
FBLN1
Experiment(s)
For this entry:
FBLN1_HUMAN (FBLN1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 703 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 98 | Glyconnect |
|
29741879 |
| 98 | UniProtKB | 19139490 | |
| 98 | UniPep | ||
| 98 | PolarProtDb | 31844046 | |
| 98 | N-GlycoSiteAtlas | 26571101 | |
| 98 | dbPTM | 19139490 | |
| 98 | GPTwiki |
|
|
| 98 | Glyconnect |
|
29741879 , 29671580 |
| 98 | Glyconnect |
|
29741879 |
| 98 | Glyconnect |
|
29741879 |
| 98 | Glyconnect |
|
29741879 |
| 98 | Glyconnect |
|
29741879 |
| 98 | UniCarbKB |
|
29671580 |
| 489 | UniCarbKB |
|
30459171 |
| 535 | UniPep | ||
| 535 | N-GlycoSiteAtlas | 24495048 | |
| 535 | Glyconnect |
|
29741879 |
| 535 | Glyconnect |
|
29741879 |
| 539 | UniPep | ||
| 539 | N-GlycoSiteAtlas | 24495048 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Anaphylatoxin/fibulin |
| InterPro | cEGF |
| InterPro | EGF-like_Ca-bd_dom |
| InterPro | EGF-like_dom |
| InterPro | EGF-type_Asp/Asn_hydroxyl_site |
| InterPro | EGF_Ca-bd_CS |
| InterPro | Fibulin-1 |
| InterPro | Growth_fac_rcpt_cys_sf |
| Pfam | cEGF |
| Pfam | EGF_CA |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| 1433T_HUMAN | 2 | 21988832 |
| SMAD3_HUMAN | 2 | 21988832 |
| ATN1_HUMAN | 2 | 16713569 |
| NLGN3_HUMAN | 2 | 25464930 |
| APOA1_HUMAN | 2 | 21988832 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.