PolarProtDb

Gene name

Egfr (ERBB,ERBB1,HER1)

Experiment(s)

For this entry:

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	24	Signal peptide
25	650	Extracellular
651	669	Membrane
670	1210	Cytoplasmic

Phosphorylation

Position	Resource
270	457625
316	456989
695	448054
697	451484
729	457949
871	448061
993	455701
995	2408907
997	465630
1000	452118
1018	448055
1034	27996385
1041	3178884
1043	3178896
1044	3178887
1057	22554006
1069	448056
1070	448051
1071	448052
1074	4834046
1092	448057
1104	14910702
1110	448058
1138	457950
1162	487358
1166	452120
1172	448059
1197	448060

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
175	dbPTM		17330941
175	UniProtKB		17330941
352	Glyconnect	$WURCS=2.0/2,8,7/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?$	30899004
352	dbPTM		16944957
352	UniProtKB		16944957
444	dbPTM		16944957
444	UniProtKB		16944957

Family and domain data

Database	Domain/Family name
InterPro	Furin-like_Cys-rich_dom
InterPro	Furin_repeat
InterPro	GF_recep_IV
InterPro	Growth_fac_rcpt_cys_sf
InterPro	Kinase-like_dom_sf
InterPro	Prot_kinase_dom
InterPro	Protein_kinase_ATP_BS
InterPro	Rcpt_L-dom
InterPro	Rcpt_L-dom_sf
InterPro	Ser-Thr/Tyr_kinase_cat_dom
InterPro	Tyr_kinase_AS
InterPro	Tyr_kinase_cat_dom
InterPro	Tyr_kinase_EGF/ERB/XmrK_rcpt
Pfam	Furin-like
Pfam	GF_recep_IV
Pfam	PK_Tyr_Ser-Thr
Pfam	Recep_L_domain

Interactions

With (links to EBI)	#Exp	PubMed links
RASK_MOUSE	3	22975374

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.