Gene name
Egfr (ERBB,ERBB1,HER1)
Experiment(s)
For this entry:
F1PF03_CANLF (Egfr)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | The dog gene is incomplete at its N-terminus (due to poor genome sequence quality) |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 582 | Extracellular |
| 583 | 602 | Membrane |
| 603 | 1141 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Furin-like_Cys-rich_dom |
| InterPro | Furin_repeat |
| InterPro | GF_recep_IV |
| InterPro | Growth_fac_rcpt_cys_sf |
| InterPro | Kinase-like_dom_sf |
| InterPro | Prot_kinase_dom |
| InterPro | Protein_kinase_ATP_BS |
| InterPro | Rcpt_L-dom |
| InterPro | Rcpt_L-dom_sf |
| InterPro | Ser-Thr/Tyr_kinase_cat_dom |
| InterPro | Tyr_kinase_AS |
| InterPro | Tyr_kinase_cat_dom |
| InterPro | Tyr_kinase_EGF/ERB/XmrK_rcpt |
| Pfam | Furin-like |
| Pfam | GF_recep_IV |
| Pfam | PK_Tyr_Ser-Thr |
| Pfam | Recep_L_domain |