PolarProtDb

Gene name

COL18A1

Experiment(s)

For this entry:

COIA1_HUMAN (COL18A1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Uhlén M,Fagerberg L,Hallström BM,Lindskog C,Oksvold P,Mardinoglu A,Sivertsson Å,Kampf C,Sjöstedt E,Asplund A,Olsson I,Edlund K,Lundberg E,Navani S,Szigyarto CA,Odeberg J,Djureinovic D,Takanen JO,Hober S,Alm T,Edqvist PH,Berling H,Tegel H,Mulder J,Rockberg J,Nilsson P,Schwenk JM,Hamsten M,von Feilitzen K,Forsberg M,Persson L,Johansson F,Zwahlen M,von Heijne G,Nielsen J,Pontén F (2015) Proteomics. Tissue-based map of the human proteome., Science, 347, 1260419. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Liver
Cell	Hepatocytes
Notes	Inferred from the Human Tissue Atlas

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	1754	Extracellular

Phosphorylation

Position	Resource
93	34498643
99	34499447
696	34502782
697	34504369
704	34498934
705	27446557
706	34501556
709	34500975
711	34501559
1211	10282175
1245	18909594
1450	23095175
1588	55372139

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
43	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
43	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
43	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
79	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
93	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
95	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
95	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
96	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
129	N-GlycoSiteAtlas		24495048
129	Glyconnect	$WURCS=2.0/2,10,9/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?$	29741879
142	O-GlycoProteomDB
147	O-GlycoProteomDB
164	N-GlycoSiteAtlas		24495048
192	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
192	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
194	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
472	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
474	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
696	O-GlycoProteomDB
696	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
696	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
696	UniCarbKB		30459171
697	O-GlycoProteomDB
697	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
697	UniCarbKB		30459171
706	O-GlycoProteomDB
709	O-GlycoProteomDB
718	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
718	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
718	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
718	O-GlycoProteomDB
718	UniCarbKB	$WURCS=2.0/1,2,1/[uxxxxh_2*NCC/3=O]/1-1/a?\|b?}-{a?\|b?$	30459171
719	O-GlycoProteomDB
719	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
719	UniCarbKB		30459171
727	O-GlycoProteomDB
727	UniCarbKB	$WURCS=2.0/2,3,2/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	30459171
727	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
727	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
727	UniCarbKB		30459171
731	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-1-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
731	UniCarbKB	$WURCS=2.0/2,4,3/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2/a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?_a?\|b?\|c?\|d?}-{a?\|b?\|c?\|d?$	30459171
731	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
731	UniCarbKB		30459171
733	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
733	UniCarbKB		30459171
735	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
735	O-GlycoProteomDB
736	UniCarbKB		30459171
736	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
736	O-GlycoProteomDB
740	PolarProtDb		29296958
740	O-GlycoProteomDB
743	PolarProtDb		29296958
743	O-GlycoProteomDB
799	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
926	N-GlycoSiteAtlas		24495048
1527	dbPTM		55829081
1527	PolarProtDb		29296958
1527	PhosphoSitePlus
1527	PolarProtDb		29296958
1527	O-GlycoProteomDB
1539	O-GlycoProteomDB
1539	UniCarbKB		30459171
1539	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1539	PolarProtDb		29296958
1539	PhosphoSitePlus
1539	dbPTM		55828291
1556	O-GlycoProteomDB
1556	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1556	UniCarbKB		30459171
1567	UniCarbKB		10441114
1567	UniCarbKB		30459171
1567	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1567	PolarProtDb		29296958
1567	UniProtKB		10441114
1711	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
1717	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171

Family and domain data

Database	Domain/Family name
InterPro	C-type_lectin-like/link_sf
InterPro	Collagen
InterPro	Collagen_XVIII_Fz
InterPro	Collagenase_NC10/endostatin
InterPro	ConA-like_dom_sf
InterPro	CTDL_fold
InterPro	DUF959_COL18_N
InterPro	Frizzled_dom
InterPro	Frizzled_dom_sf
InterPro	Laminin_G
Pfam	Collagen
Pfam	DUF959
Pfam	Endostatin
Pfam	Fz

Interactions

With (links to EBI)	#Exp	PubMed links
ESR1_HUMAN	2	31527615

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.