PolarProtDb

Gene name

B2M

Experiment(s)

For this entry:

B2MG_HUMAN (B2M)

Species	Homo sapiens
Localization	Non polar membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	119	Extracellular

Phosphorylation

Position	Resource
4	23085420
14	23085414
24	23085423
30	3584578
31	23085417
72	54413435
75	36130856
77	54413439
108	54413443

Glycosylation

Position	Site resource	PubMed link(s)
31	O-GlycoProteomDB
48	O-GlycoProteomDB
93	O-GlycoProteomDB
106	PhosphoSitePlus
106	PolarProtDb	29296958
106	PolarProtDb	29296958
106	dbPTM	55825743
106	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	B2Microglobulin
InterPro	Ig-like_dom
InterPro	Ig-like_dom_sf
InterPro	Ig-like_fold
InterPro	Ig/MHC_CS
InterPro	Ig_C1-set
Pfam	C1-set

Interactions

With (links to EBI)	#Exp	PubMed links
HLAA_HUMAN	8	20844028 , 20831383
KI3L1_HUMAN	3	27649529
Q95J06_HUMAN	2	27649529
HLAC_HUMAN	5	28546555 , 27649529 , 28514442
KI2S1_HUMAN	2	28546555
LIRB1_HUMAN	4	27649529
NCAP_CVHSA	2	20844028
VME1_CVHSA	2	20831383
CD244_HUMAN	2	20164429
KI3S1_HUMAN	3	27649529
LIRB2_HUMAN	4	27649529
HLAB_HUMAN	8	28514442 , 27649529
CD1B_HUMAN	2	28514442 , 14764708
IL27B_HUMAN	2	24018270
EBNA4_EBVB9	2	24018270
ENV_HV1Y2	2	24018270
CD1A_HUMAN	2	15723809 , 12833155
PCNA_HUMAN	2	23527218
INS_HUMAN	2	24018270
IMA1_HUMAN	3	24018270
HLAF_HUMAN	4	27649529 , 20483783
HLAA_HUMAN	19	26439010 , 24163410

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.