Gene name
Atp8b1 (ATPIC,FIC1,PFIC)
Experiment(s)
For this entry:
AT8B1_HUMAN (Atp8b1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Verhulst PM,van der Velden LM,Oorschot V,van Faassen EE,Klumperman J,Houwen RH,Pomorski TG,Holthuis JC,Klomp LW (2010) A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells., Hepatology, 51, 2049-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes |
AT8B1_HUMAN (Atp8b1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Eppens EF,van Mil SW,de Vree JM,Mok KS,Juijn JA,Oude Elferink RP,Berger R,Houwen RH,Klomp LW (2001) FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte., J Hepatol, 35, 436-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 118 | Cytoplasmic |
| 119 | 136 | Membrane |
| 137 | 140 | Extracellular |
| 141 | 157 | Membrane |
| 158 | 339 | Cytoplasmic |
| 340 | 361 | Membrane |
| 362 | 385 | Extracellular |
| 386 | 406 | Membrane |
| 407 | 950 | Cytoplasmic |
| 951 | 971 | Membrane |
| 972 | 982 | Extracellular |
| 983 | 1003 | Membrane |
| 1004 | 1032 | Cytoplasmic |
| 1033 | 1053 | Membrane |
| 1054 | 1069 | Extracellular |
| 1070 | 1090 | Membrane |
| 1091 | 1099 | Cytoplasmic |
| 1100 | 1120 | Membrane |
| 1121 | 1142 | Extracellular |
| 1143 | 1163 | Membrane |
| 1164 | 1251 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 368 | N-GlycoSiteAtlas | 24495048 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ATP8B1 |
| InterPro | ATPase_P-typ_cyto_dom_N |
| InterPro | ATPase_P-typ_P_site |
| InterPro | ATPase_P-typ_TM_dom_sf |
| InterPro | ATPase_P-typ_transduc_dom_A_sf |
| InterPro | HAD-like_sf |
| InterPro | P-type_ATPase_IV |
| InterPro | P-type_ATPase_N |
| InterPro | P_typ_ATPase |
| InterPro | P_typ_ATPase_c |
| Pfam | PhoLip_ATPase_C |
| Pfam | PhoLip_ATPase_N |