PolarProtDb

Gene name

ARSA

Experiment(s)

For this entry:

ARSA_HUMAN (ARSA)

Species	Homo sapiens
Localization	Non polar membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	507	Extracellular

Glycosylation

Position	Site resource	PubMed link(s)
158	PDB	12888274
158	PDB	12888274
158	UniCarbKB	10814696
158	dbPTM	12888274 , 19159218
158	N-GlycoSiteAtlas	24495048
158	UniProtKB	12888274 , 19159218
158	UniCarbKB	10814696 , 19864504
184	PDB	11777924
184	UniProtKB	12888274
184	UniPep
184	N-GlycoSiteAtlas	26571101
184	dbPTM	12888274
184	UniCarbKB	19864504
184	UniCarbKB	19864504
184	UniCarbKB	19864504
184	PDB	12888274
184	PDB	12888274
184	UniCarbKB	19864504
184	PDB	9521684
184	UniCarbKB	19864504
350	UniCarbKB	19864504
350	UniProtKB	19159218
350	UniPep
350	N-GlycoSiteAtlas	19159218
350	dbPTM	19159218
350	UniCarbKB	19864504
350	UniCarbKB	19864504
350	UniCarbKB	19864504
409	O-GlycoProteomDB
471	PolarProtDb	29296958
471	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Alkaline_phosphatase_core_sf
InterPro	Sulfatase_CS
InterPro	Sulfatase_N
Pfam	Sulfatase

Interactions

With (links to EBI)	#Exp	PubMed links
KCC2B_HUMAN	3	32296183
FOXI1_HUMAN	3	32296183
PROP1_HUMAN	3	32296183
EID2B_HUMAN	3	32296183
VENTX_HUMAN	3	32296183
ANX11_HUMAN	3	32296183
ENKD1_HUMAN	3	32296183
PKN1_HUMAN	3	32296183
CCD22_HUMAN	3	32296183
CV039_HUMAN	3	32296183
PIT1_HUMAN	3	32296183
PCH2_HUMAN	12	25910212 , 26871637 , 25416956 , 32296183
RHXF2_HUMAN	3	32296183

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.