Gene name
ANO1 (DOG1,ORAOV2,TAOS2,TMEM16A)
Experiment(s)
For this entry:
ANO1_HUMAN (ANO1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Iosco C,Cosentino C,Sirna L,Romano R,Cursano S,Mongia A,Pompeo G,di Bernardo J,Ceccarelli C,Tallini G,Rhoden KJ (2014) Anoctamin 1 is apically expressed on thyroid follicular cells and contributes to ATP- and calcium-activated iodide efflux., Cell Physiol Biochem, 34, 966-80. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Thyroid gland |
| Cell | Follicular cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 331 | Cytoplasmic |
| 332 | 354 | Membrane |
| 355 | 407 | Extracellular |
| 408 | 426 | Membrane |
| 427 | 516 | Cytoplasmic |
| 517 | 539 | Membrane |
| 540 | 562 | Extracellular |
| 563 | 582 | Membrane |
| 583 | 609 | Cytoplasmic |
| 610 | 628 | Membrane |
| 629 | 732 | Extracellular |
| 733 | 755 | Membrane |
| 756 | 785 | Cytoplasmic |
| 786 | 807 | Membrane |
| 808 | 884 | Extracellular |
| 885 | 904 | Membrane |
| 905 | 986 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 7 | 475370 |
| 8 | 15229820 |
| 9 | 2463106 |
| 54 | 23153458 |
| 64 | 55376445 |
| 78 | 34501428 |
| 86 | 34501482 |
| 88 | 50773178 |
| 94 | 34501259 |
| 107 | 34502091 |
| 119 | 474488 |
| 182 | 4132679 |
| 187 | 23153455 |
| 196 | 23153446 |
| 221 | 27443636 |
| 243 | 55376448 |
| 251 | 11104994 |
| 302 | 11104998 |
| 314 | 10848268 |
| 466 | 5966501 |
| 471 | 50773175 |
| 555 | 23153449 |
| 974 | 27443633 |
| 978 | 23153452 |
| 981 | 473035 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 375 | N-GlycoSiteAtlas | 21621025 , 25247386 , 24495048 | |
| 375 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Anoct_dimer |
| InterPro | Anoctamin |
| InterPro | Anoctamin-1 |
| Pfam | Anoct_dimer |
| Pfam | Anoctamin |