Gene name
ANO1 (DOG1,ORAOV2,TAOS2,TMEM16A)
Experiment(s)
For this entry:
A0A0G2K052_RAT (ANO1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Silveira JC,Kopp PA (2015) Pendrin and anoctamin as mediators of apical iodide efflux in thyroid cells., Curr Opin Endocrinol Diabetes Obes, 22, 374-80. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Thyroid gland |
| Cell | Follicular cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 353 | Cytoplasmic |
| 354 | 376 | Membrane |
| 377 | 429 | Extracellular |
| 430 | 448 | Membrane |
| 449 | 512 | Cytoplasmic |
| 513 | 535 | Membrane |
| 536 | 558 | Extracellular |
| 559 | 579 | Membrane |
| 580 | 605 | Cytoplasmic |
| 606 | 625 | Membrane |
| 626 | 728 | Extracellular |
| 729 | 751 | Membrane |
| 752 | 781 | Cytoplasmic |
| 782 | 803 | Membrane |
| 804 | 880 | Extracellular |
| 881 | 900 | Membrane |
| 901 | 982 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Anoct_dimer |
| InterPro | Anoctamin |
| InterPro | Anoctamin-1 |
| Pfam | Anoct_dimer |
| Pfam | Anoctamin |