Gene name
Adgrg2 (Gpr64,HE6,TM7LN2,Me6)
Experiment(s)
For this entry:
AGRG2_HUMAN (Adgrg2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Obermann H,Samalecos A,Osterhoff C,Schröder B,Heller R,Kirchhoff C (2003) HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia., Mol Reprod Dev, 64, 13-26. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Epididymis |
| Cell | Principal cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 37 | Signal peptide |
| 38 | 629 | Extracellular |
| 630 | 653 | Membrane |
| 654 | 663 | Cytoplasmic |
| 664 | 683 | Membrane |
| 684 | 693 | Extracellular |
| 694 | 714 | Membrane |
| 715 | 737 | Cytoplasmic |
| 738 | 756 | Membrane |
| 757 | 786 | Extracellular |
| 787 | 810 | Membrane |
| 811 | 833 | Cytoplasmic |
| 834 | 852 | Membrane |
| 853 | 861 | Extracellular |
| 862 | 882 | Membrane |
| 883 | 1017 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 97 | O-GlycoProteomDB | ||
| 99 | PolarProtDb | 31844046 | |
| 99 | N-GlycoSiteAtlas | 19530676 , 25732060 , 25902405 | |
| 101 | O-GlycoProteomDB | ||
| 111 | N-GlycoSiteAtlas | 19530676 , 22106898 | |
| 117 | N-GlycoSiteAtlas | 19530676 , 22106898 | |
| 144 | N-GlycoSiteAtlas | ||
| 194 | N-GlycoSiteAtlas | 22106898 , 23820512 | |
| 256 | O-GlycoProteomDB | ||
| 257 | O-GlycoProteomDB | ||
| 258 | O-GlycoProteomDB | ||
| 260 | O-GlycoProteomDB | ||
| 268 | O-GlycoProteomDB | ||
| 268 | PhosphoSitePlus |
![WURCS=2.0/1,1,0/[a2112h-1x_1-5_2*NCC/3=O]/1/](data:image/png;base64,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)
|
|
| 268 | dbPTM | 55831723 | |
| 271 | O-GlycoProteomDB | ||
| 271 | PhosphoSitePlus |
|
|
| 271 | dbPTM | 55831729 | |
| 277 | PhosphoSitePlus |
|
|
| 277 | O-GlycoProteomDB | ||
| 277 | dbPTM | 55832817 | |
| 286 | O-GlycoProteomDB | ||
| 289 | O-GlycoProteomDB | ||
| 294 | O-GlycoProteomDB | ||
| 326 | O-GlycoProteomDB | ||
| 327 | O-GlycoProteomDB | ||
| 332 | O-GlycoProteomDB | ||
| 335 | O-GlycoProteomDB | ||
| 337 | O-GlycoProteomDB | ||
| 542 | N-GlycoSiteAtlas | 24495048 | |
| 542 | PolarProtDb | 31844046 | |
| 551 | N-GlycoSiteAtlas | ||
| 597 | N-GlycoSiteAtlas | ||
| 597 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | GPCR_2-like |
| InterPro | GPCR_2_secretin-like |
| InterPro | GPCR_2_secretin-like_CS |
| InterPro | GPS |
| Pfam | 7tm_2 |
| Pfam | GPS |