Gene name
Abcb11 (Bsep,Spgp)
Experiment(s)
For this entry:
ABCBB_MOUSE (Abcb11)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Homolya L,Fu D,Sengupta P,Jarnik M,Gillet JP,Vitale-Cross L,Gutkind JS,Lippincott-Schwartz J,Arias IM (2014) LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes., PLoS One, 9, e91921. [PubMed] [DOI] |
| Evidence level | Functional assay |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes | A functional transporte assay was used |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 59 | Cytoplasmic |
| 60 | 81 | Membrane |
| 82 | 144 | Extracellular |
| 145 | 162 | Membrane |
| 163 | 217 | Cytoplasmic |
| 218 | 235 | Membrane |
| 236 | 242 | Extracellular |
| 243 | 259 | Membrane |
| 260 | 323 | Cytoplasmic |
| 324 | 341 | Membrane |
| 342 | 362 | Extracellular |
| 363 | 379 | Membrane |
| 380 | 754 | Cytoplasmic |
| 755 | 772 | Membrane |
| 773 | 800 | Extracellular |
| 801 | 818 | Membrane |
| 819 | 876 | Cytoplasmic |
| 877 | 894 | Membrane |
| 895 | 901 | Extracellular |
| 902 | 918 | Membrane |
| 919 | 981 | Cytoplasmic |
| 982 | 998 | Membrane |
| 999 | 1019 | Extracellular |
| 1020 | 1037 | Membrane |
| 1038 | 1321 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | BSEP |
| InterPro | P-loop_NTPase |
| InterPro | Type_I_exporter |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |