Gene name
Abcb11 (Bsep,Spgp)
Experiment(s)
For this entry:
ABCBB_HUMAN (Abcb11)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Jansen PL,Strautnieks SS,Jacquemin E,Hadchouel M,Sokal EM,Hooiveld GJ,Koning JH,De Jager-Krikken A,Kuipers F,Stellaard F,Bijleveld CM,Gouw A,Van Goor H,Thompson RJ,Müller M (1999) Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis., Gastroenterology, 117, 1370-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 59 | Cytoplasmic |
| 60 | 81 | Membrane |
| 82 | 143 | Extracellular |
| 144 | 165 | Membrane |
| 166 | 213 | Cytoplasmic |
| 214 | 235 | Membrane |
| 236 | 242 | Extracellular |
| 243 | 263 | Membrane |
| 264 | 319 | Cytoplasmic |
| 320 | 341 | Membrane |
| 342 | 362 | Extracellular |
| 363 | 383 | Membrane |
| 384 | 751 | Cytoplasmic |
| 752 | 773 | Membrane |
| 774 | 801 | Extracellular |
| 802 | 823 | Membrane |
| 824 | 873 | Cytoplasmic |
| 874 | 894 | Membrane |
| 895 | 901 | Extracellular |
| 902 | 919 | Membrane |
| 920 | 979 | Cytoplasmic |
| 980 | 1000 | Membrane |
| 1001 | 1021 | Extracellular |
| 1022 | 1039 | Membrane |
| 1040 | 1321 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 109 | dbPTM | 17082223 | |
| 109 | N-GlycoSiteAtlas | 25207853 | |
| 109 | UniProtKB | 17082223 | |
| 116 | dbPTM | 17082223 | |
| 116 | N-GlycoSiteAtlas | 25207853 | |
| 116 | UniProtKB | 17082223 | |
| 122 | dbPTM | 17082223 | |
| 122 | N-GlycoSiteAtlas | 25207853 | |
| 122 | UniProtKB | 17082223 | |
| 125 | dbPTM | 17082223 | |
| 125 | N-GlycoSiteAtlas | 25207853 | |
| 125 | UniProtKB | 17082223 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | BSEP |
| InterPro | P-loop_NTPase |
| InterPro | Type_I_exporter |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| DDT4L_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.