Gene name
ATP6V0A4 (ATP6N1B,ATP6N2)
Experiment(s)
For this entry:
VPP4_HUMAN (ATP6V0A4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Stehberger PA,Schulz N,Finberg KE,Karet FE,Giebisch G,Lifton RP,Geibel JP,Wagner CA (2003) Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis., J Am Soc Nephrol, 14, 3027-38. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Alpha intercalated cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 393 | Cytoplasmic |
| 394 | 409 | Membrane |
| 410 | 411 | Extracellular |
| 412 | 427 | Membrane |
| 428 | 443 | Cytoplasmic |
| 444 | 465 | Membrane |
| 466 | 542 | Extracellular |
| 543 | 564 | Membrane |
| 565 | 574 | Cytoplasmic |
| 575 | 596 | Membrane |
| 597 | 640 | Extracellular |
| 641 | 657 | Membrane |
| 658 | 770 | Cytoplasmic |
| 771 | 796 | Membrane |
| 797 | 840 | Extracellular |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | V-ATPase_116kDa_su |
| InterPro | V-type_ATPase_116kDa_su_euka |
| Pfam | V_ATPase_I |