Gene name
USH2A (Gm676)
Experiment(s)
For this entry:
USH2A_MOUSE (USH2A)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Liu X,Bulgakov OV,Darrow KN,Pawlyk B,Adamian M,Liberman MC,Li T (2007) Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells., Proc Natl Acad Sci U S A, 104, 4413-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Inner ear |
| Cell | Hair cells |
| Notes |
USH2A_MOUSE (USH2A)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Liu X,Bulgakov OV,Darrow KN,Pawlyk B,Adamian M,Liberman MC,Li T (2007) Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells., Proc Natl Acad Sci U S A, 104, 4413-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Retina |
| Cell | Photoreceptor cells |
| Notes | Located to the stem of ciliary segments |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 8 | Cytoplasmic |
| 9 | 31 | Membrane |
| 32 | 5031 | Extracellular |
| 5032 | 5054 | Membrane |
| 5055 | 5193 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 5189 | 5193 | TDTHL | TRG_PTS1 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ConA-like_dom_sf |
| InterPro | FN3_dom |
| InterPro | FN3_sf |
| InterPro | Ig-like_fold |
| InterPro | LamG-like |
| InterPro | Laminin_EGF |
| InterPro | Laminin_G |
| InterPro | Laminin_N |
| InterPro | Laminin_N_sf |
| InterPro | USH2A |
| Pfam | fn3 |
| Pfam | Laminin_EGF |
| Pfam | Laminin_G_1 |
| Pfam | Laminin_G_2 |
| Pfam | Laminin_N |