PolarProtDb

Gene name

PLAU

Experiment(s)

For this entry:

UROK_HUMAN (PLAU)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes	Only mock-transfected cells were considered

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	431	Extracellular

Phosphorylation

Position	Resource
38	23071222
41	23071219
158	451052
323	451053

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
38	PDB		8161544
38	dbPTM		2023947
38	OGlycoBase		91219498
38	UniProtKB		2023947
158	PhosphoSitePlus
158	PolarProtDb		29296958
158	dbPTM		23949
158	O-GlycoProteomDB
322	Glyconnect		1468573 , 2393398 , 2023947
322	UniCarbKB		1468573 , 2393398 , 2023947
322	Glyconnect	$WURCS=2.0/3,11,10/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-3-3-3/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	1468573
322	Glyconnect		1468573 , 2393398 , 2023947
322	UniCarbKB		1468573 , 2393398 , 2023947
322	N-GlycoSiteAtlas		17506567 , 19530676 , 18792917 , 21621025 , 22457533 , 24164404 , 24324730 , 23820512 , 25285165 , 25244057 , 25247386
322	PolarProtDb		31844046
356	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	EGF-like_dom
InterPro	Kringle
InterPro	Kringle-like
InterPro	Kringle_CS
InterPro	Kringle_sf
InterPro	Peptidase_S1_PA
InterPro	Peptidase_S1_PA_chymotrypsin
InterPro	Peptidase_S1A
InterPro	Trypsin_dom
InterPro	TRYPSIN_HIS
InterPro	TRYPSIN_SER
InterPro	Urokinase
Pfam	Kringle
Pfam	Trypsin

Interactions

With (links to EBI)	#Exp	PubMed links
UPAR_HUMAN	2	24457100
ANGI_HUMAN	2	24457100
ADA28_HUMAN	3	32296183
KPCD1_HUMAN	2	31980649

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.