Gene name
Upk3a (Upk3,Upk3a_predicted)
Experiment(s)
For this entry:
UPK3A_HUMAN (Upk3a)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Višnjar T,Chesi G,Iacobacci S,Polishchuk E,Resnik N,Robenek H,Kreft M,Romih R,Polishchuk R,Kreft ME (2017) Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models., Sci Rep, 7, 12842. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Part of the obligatory heterodimer UPKIb-UPKIIIa |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Signal peptide |
| 20 | 208 | Extracellular |
| 209 | 232 | Membrane |
| 233 | 287 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 74 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Uroplakin-3 |
| InterPro | Uroplakin-3a |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| SGTA_HUMAN | 3 | 25416956 |
| SGTB_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.