Gene name
UPK1B (TSPAN20)
Experiment(s)
For this entry:
UPK1B_HUMAN (UPK1B)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Višnjar T,Chesi G,Iacobacci S,Polishchuk E,Resnik N,Robenek H,Kreft M,Romih R,Polishchuk R,Kreft ME (2017) Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models., Sci Rep, 7, 12842. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Part of the obligatory heterodimer UPKIb-UPKIIIa |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Cytoplasmic |
| 14 | 36 | Membrane |
| 37 | 56 | Extracellular |
| 57 | 78 | Membrane |
| 79 | 87 | Cytoplasmic |
| 88 | 110 | Membrane |
| 111 | 232 | Extracellular |
| 233 | 254 | Membrane |
| 255 | 260 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 184 | 23071269 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 131 | N-GlycoSiteAtlas | 26571101 | |
| 131 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Tetraspanin |
| InterPro | Tetraspanin/Peripherin |
| InterPro | Tetraspanin_EC2_sf |
| InterPro | Uroplakin-1b |
| Pfam | Tetraspanin |
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.