Gene name
TRPM7 (CHAK1,Ltrpc7,Chak)
Experiment(s)
For this entry:
TRPM7_MOUSE (TRPM7)
| Species | Mus musculus |
|---|---|
| Localization | Non polar membrane |
| Reference |
Yu W,Hill WG,Apodaca G,Zeidel ML (2011) Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium., Am J Physiol Renal Physiol, 300, F49-59. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Bladder |
| Cell | Urothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 758 | Extracellular |
| 759 | 774 | Membrane |
| 775 | 855 | Cytoplasmic |
| 856 | 876 | Membrane |
| 877 | 885 | Extracellular |
| 886 | 901 | Membrane |
| 902 | 922 | Cytoplasmic |
| 923 | 943 | Membrane |
| 944 | 959 | Extracellular |
| 960 | 980 | Membrane |
| 981 | 996 | Cytoplasmic |
| 997 | 1021 | Membrane |
| 1022 | 1074 | Extracellular |
| 1075 | 1096 | Membrane |
| 1097 | 1863 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 9 | 14571493 |
| 10 | 14571496 |
| 12 | 14571499 |
| 552 | 40509893 |
| 555 | 3952710 |
| 1224 | 22831200 |
| 1255 | 2512900 |
| 1258 | 2512936 |
| 1269 | 15499490 |
| 1271 | 2512926 |
| 1300 | 7101587 |
| 1360 | 31909861 |
| 1385 | 22831201 |
| 1386 | 2512908 |
| 1394 | 25734201 |
| 1398 | 25734205 |
| 1403 | 2512922 |
| 1404 | 2512940 |
| 1406 | 2512939 |
| 1412 | 23093441 |
| 1445 | 2512907 |
| 1466 | 3827468 |
| 1480 | 2512905 |
| 1488 | 4770148 |
| 1491 | 467645 |
| 1496 | 467646 |
| 1498 | 3252622 |
| 1502 | 479904 |
| 1503 | 480441 |
| 1506 | 2512938 |
| 1511 | 455463 |
| 1565 | 2512914 |
| 1567 | 455464 |
| 1613 | 2512930 |
| 1846 | 4770153 |
| 1849 | 2512937 |
| 1858 | 2512924 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ion_trans_dom |
| InterPro | Kinase-like_dom_sf |
| InterPro | MHCK_EF2_kinase |
| InterPro | TRPM7 |
| InterPro | TRPM_SLOG |
| InterPro | TRPM_tetra |
| InterPro | TRPM_tetra_sf |
| Pfam | Alpha_kinase |
| Pfam | Ion_trans |
| Pfam | LSDAT_euk |
| Pfam | TRPM_tetra |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| RUVB2_MOUSE | 2 | 24855944 |
| DESP_MOUSE | 2 | 24855944 |
| HNRH1_MOUSE | 2 | 24855944 |
| RYBP_HUMAN | 3 | 24855944 |
| DDX17_MOUSE | 2 | 24855944 |
| DDX3X_HUMAN | 2 | 24855944 |
| RING2_HUMAN | 2 | 24855944 |
| RUVB1_MOUSE | 2 | 24855944 |
| DDB1_MOUSE | 2 | 24855944 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.