Gene name
Trpm6
Experiment(s)
For this entry:
TRPM6_MOUSE (Trpm6)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Glaudemans B,van der Wijst J,Scola RH,Lorenzoni PJ,Heister A,van der Kemp AW,Knoers NV,Hoenderop JG,Bindels RJ (2009) A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia., J Clin Invest, 119, 936-42. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
TRPM6_MOUSE (Trpm6)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Voets T,Nilius B,Hoefs S,van der Kemp AW,Droogmans G,Bindels RJ,Hoenderop JG (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption., J Biol Chem, 279, 19-25. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
TRPM6_MOUSE (Trpm6)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Voets T,Nilius B,Hoefs S,van der Kemp AW,Droogmans G,Bindels RJ,Hoenderop JG (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption., J Biol Chem, 279, 19-25. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 750 | Extracellular |
| 751 | 766 | Membrane |
| 767 | 847 | Cytoplasmic |
| 848 | 868 | Membrane |
| 869 | 874 | Extracellular |
| 875 | 890 | Membrane |
| 891 | 914 | Cytoplasmic |
| 915 | 933 | Membrane |
| 934 | 945 | Extracellular |
| 946 | 964 | Membrane |
| 965 | 982 | Cytoplasmic |
| 983 | 1001 | Membrane |
| 1002 | 1056 | Extracellular |
| 1057 | 1075 | Membrane |
| 1076 | 1105 | Cytoplasmic |
| 1106 | 1121 | Membrane |
| 1122 | 2028 | Extracellular |
Phosphorylation
| Position | Resource |
|---|---|
| 1753 | 5831083 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ion_trans_dom |
| InterPro | Kinase-like_dom_sf |
| InterPro | MHCK_EF2_kinase |
| InterPro | TRPM6 |
| InterPro | TRPM_SLOG |
| InterPro | TRPM_tetra |
| InterPro | TRPM_tetra_sf |
| Pfam | Alpha_kinase |
| Pfam | Ion_trans |
| Pfam | LSDAT_euk |
| Pfam | TRPM_tetra |