Gene name
Trpc3 (TRP3)
Experiment(s)
For this entry:
TRPC3_HUMAN (Trpc3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bandyopadhyay BC,Swaim WD,Liu X,Redman RS,Patterson RL,Ambudkar IS (2005) Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx., J Biol Chem, 280, 12908-16. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A HA tag was used for imaging. Authors were silent about the clone source |
TRPC3_HUMAN (Trpc3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bandyopadhyay BC,Swaim WD,Liu X,Redman RS,Patterson RL,Ambudkar IS (2005) Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx., J Biol Chem, 280, 12908-16. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Salivary gland |
| Cell | SMIE cells (ductal cells) |
| Notes | A HA tag was used for imaging. Authors were silent about the clone source |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 337 | Cytoplasmic |
| 338 | 358 | Membrane |
| 359 | 370 | Extracellular |
| 371 | 391 | Membrane |
| 392 | 421 | Cytoplasmic |
| 422 | 439 | Membrane |
| 440 | 458 | Extracellular |
| 459 | 480 | Membrane |
| 481 | 523 | Cytoplasmic |
| 524 | 544 | Membrane |
| 545 | 564 | Extracellular |
| 565 | 586 | Membrane |
| 587 | 607 | Cytoplasmic |
| 608 | 624 | Membrane |
| 625 | 636 | Extracellular |
| 637 | 658 | Membrane |
| 659 | 836 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ankyrin_rpt |
| InterPro | Ankyrin_rpt-contain_dom |
| InterPro | Ankyrin_rpt-contain_sf |
| InterPro | Ion_trans_dom |
| InterPro | TRP_dom |
| InterPro | TRPC3_channel |
| InterPro | TRPC_channel |
| Pfam | Ank_2 |
| Pfam | Ion_trans |
| Pfam | TRP_2 |