Gene name
TIMP1 (Timp-1,TIMP,CLGI)
Experiment(s)
For this entry:
TIMP1_HUMAN (TIMP1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Lung |
| Cell | Airway epithel cells |
| Notes | Only mock-transfected cells were considered |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 207 | Extracellular |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Netrin_domain |
| InterPro | TIMP |
| InterPro | TIMP-like_OB-fold |
| InterPro | TIMP1 |
| InterPro | TIMP_C |
| InterPro | TIMP_CS |
| Pfam | TIMP |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CD63_HUMAN | 3 | 28030805 |
| CD82_HUMAN | 12 | 28030805 |
| MMP9_HUMAN | 3 | 24330623 , 28514442 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.